UGT1A4 isoform is part of the UGT1A complex locus which displays alternative use of promoters, first exons and terminal exons. Our findings therefore indicate that UGT1A4‐mediated metabolism is not a major contributor to interpatient variability in olanzapine levels. The locus is defined by 13 first exons, which are alternatively spliced to 3 other common exons and 2 alternative terminal exons 5. UGT1A4 UM *1a/*3b [Increased activity] Ultrarapid metabolizer: Risk of decreased serum levels. Labs this year that may be of interest: (Genesight, others) I was found to be homozygous for 677T, CYP2C9 Poor Metabolizer, UGT1A4 Ultrarapid Metabolizer, COMT MET/MET, ADRA2A C/C. The patient is expected to have normal: enzyme activity. Specifically UGT1A4 Was going over some old results and looking into things and I am an Ultrarapid Metabolizer for UGT1A4, which when I look up mentions rapid clearance of hormones, and specifically mentioned testosterone. However, with respect to other drugs for which UGT1A4 has a dominant role in clearance, increased glucuronidation encoded by UGT1A4*3 might impact the risk for subtherapeutic drug exposure. from psychiatrist: A woman with pronounced adverse effects (UGT1A4*3) increased glucuronidation’’ from GP: A male with chronic ischaemic pain in legs; no pain relief despite very high doses of codeine – ultrarapid metabolism? The trend among fast metabolizers was quite the opposite. Cafer's Mood Stabilizers and Antiepileptics - Visualize to Memorize. I've never had a histamine level drawn, that I know of (possibly done by allergist). Poor Metabolizer Breaks down medications very slowly. CYP2D6*4/*4, poor metaboliser, no bioactivation of codeine. By using the AmpliChip CYP450 Test, out of 182 subjects, we identified 8 poor metabolizer (PM), 17 intermediate metabolizer (IM), 151 extensive metabolizer (EM) and 3 ultrarapid metabolizer (UM). May not get enough medication at normal doses. Possible adverse events associated with increased active metabolites A dose adjustment or alternate therapy may be considered U Be advised that there may be altered exposure to medications metabolized by UGT1A4 ABCB1 (rs2032583) A/G [Increased absorption/ Visit our website for text version of this Definition and app download. Those who drank one to three cups of coffee daily had a significantly reduced risk of heart attacks – suggesting that for them coffee was protective. Ultrarapid Metabolizer: UGT1A4 *1/*1: UGT1A4*1 allele enzyme activity: Normal UGT1A4*1 allele enzyme activity: Normal: This genotype is most consistent with the extensive (normal) metabolizer phenotype. My folate level has always been above register (> 25.2 ng/ml). Jason Cafer CaferMed LLC, 2020. 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